HJC0350

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Chemical Structure| 885434-70-8 同义名 : -
CAS号 : 885434-70-8
货号 : A504201
分子式 : C15H19NO2S
纯度 : 99%
分子量 : 277.38
MDL号 : MFCD05144768
存储条件：

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 35 mg/mL(126.18 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • EPAC2

    EPAC2, IC50:0.3 μM
描述 HJC0350 is a selective EPAC2 antagonist with IC50 value of 0.3μM for competing with 8-NBD-cAMP binding of EPAC2[3]. HJC0350 at 0.3μM represented inhibitory effects of the insulinotropic function of AWRK6 in the mouse pancreatic β cell line Min6 cells[4].
作用机制 HJC0350 inhibited EPAC2 in a competitive manner.[3]
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.61mL

0.72mL

0.36mL

18.03mL

3.61mL

1.80mL

36.05mL

7.21mL

3.61mL
参考文献

[1]Chen H, Tsalkova T, et al. Identification and characterization of small molecules as potent and specific EPAC2 antagonists. J Med Chem. 2013 Feb 14;56(3):952-62.

[2]Wang Q, Zhao C, et al. AWRK6, a Novel GLP-1 Receptor Agonist, Attenuates Diabetes by Stimulating Insulin Secretion. Int J Mol Sci. 2018 Oct 7;19(10). pii: E3053.

[3]Chen H, Tsalkova T, Chepurny OG, Mei FC, Holz GG, Cheng X, Zhou J. Identification and characterization of small molecules as potent and specific EPAC2 antagonists. J Med Chem. 2013 Feb 14;56(3):952-62. doi: 10.1021/jm3014162. Epub 2013 Jan 15. PMID: 23286832; PMCID: PMC3574212.

[4]Wang Q, Zhao C, Jin L, Zhang H, Miao Q, Liu H, Zhang D. AWRK6, a Novel GLP-1 Receptor Agonist, Attenuates Diabetes by Stimulating Insulin Secretion. Int J Mol Sci. 2018 Oct 7;19(10):3053. doi: 10.3390/ijms19103053. PMID: 30301245; PMCID: PMC6213269.