SB-218078
产品说明书
 |
同义名 : | - |
| CAS号 : | 135897-06-2 | |
| 货号 : | A465968 | |
| 分子式 : | C24H15N3O3 | |
| 纯度 : | 98% | |
| 分子量 : | 393.39 | |
| MDL号 : | MFCD06411452 | |
| 存储条件： |
Pure form Inert atmosphere, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively). Abrogates G2 cell cycle arrest caused by γ-irradiation and topoisomerase I inhibition. Potentiates cytotoxicity of DNA-damaging drugs, enhancing the efficacy of some chemotherapeutics. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.54mL 0.51mL 0.25mL |
12.71mL 2.54mL 1.27mL |
25.42mL 5.08mL 2.54mL |
