Geraniin

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Chemical Structure| 60976-49-0 同义名 : NSC 359346
CAS号 : 60976-49-0
货号 : A447714
分子式 : C41H28O27
纯度 : 99%+
分子量 : 952.64
MDL号 : MFCD09038731
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(110.22 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Geraniin, an active compound isolated from Geranium sibiricum, has been reported to have antioxidant and anti-inflammatory activities. Geraniin protected against CP(cisplatin)-induced nephrotoxicity by inhibiting oxidative stress and inflammatory response[3]. 2.5 µM geraniin significantly inhibited TNF-α-induced BMSCs (bone marrow-derived mesenchymal stem cells) cytotoxicity. 2.5 µM geraniin significantly reduced the expression of RunX2 and Osx miRNA in TNF-α-induced BMSCs. 2.5 µM geraniin suppressed the expression of NF-κB and p38 MAPK protein and promoted the expression of IкB-α protein in the TNF-α-induced BMSCs[4]. Geraniin mitigates LPS-elicited neural/synaptic neurodegeneration, amyloidogenesis, neuroinflammation, and cognitive impairment[5]. Geraniin significantly attenuated LPS-induced pathological changes in the lung. Geraniin also inhibited LPS-induced macrophages and neutrophils infiltration in the lung. Geraniin significantly attenuated LPS-induced elevation of MPO level. LPS-induced TNF-α, IL-6 and IL-1β production were markedly suppressed by treatment of geraniin[6]. Geraniin inhibits LPS-induced THP-1 macrophages switching to M1 phenotype through SOCS1/NF-κB pathway[7]. Geraniin was not toxic to the HFD (high-fat diet) rats but exhibited protection against glucotoxicity and lipotoxicity particularly in the pancreas of the obese rodents[8].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.05mL

0.21mL

0.10mL

5.25mL

1.05mL

0.52mL

10.50mL

2.10mL

1.05mL
参考文献

[1]Wang P, Peng X, et al. Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway. Biochim Biophys Acta. 2015 Sep;1850(9):1751-61.

[2]Xiao F, Zhai Z, et al. Geraniin suppresses RANKL-induced osteoclastogenesis in vitro and ameliorates wear particle-induced osteolysis in mouse model. Exp Cell Res. 2015 Jan 1;330(1):91-101.

[3]Jiang L, Liu Y, He P, Chen J, Liu S, Tan N. Geraniin ameliorates cisplatin-induced nephrotoxicity in mice. Free Radic Res. 2016 Aug;50(8):813-9

[4]Lu C, Gao S, Xu G. Geraniin inhibits TNF-α-induced impairments of osteogenesis through NF-κB and p38 MAPK signalling pathways in bone marrow stem cells. Stroke Vasc Neurol. 2017 Apr 21;2(2):47-52

[5]Wang D, Dong X, Wang B, Liu Y, Li S. Geraniin Attenuates Lipopolysaccharide-Induced Cognitive Impairment in Mice by Inhibiting Toll-Like Receptor 4 Activation. J Agric Food Chem. 2019 Sep 11;67(36):10079-10088

[6]Zhu G, Xin X, Liu Y, Huang Y, Li K, Wu C. Geraniin attenuates LPS-induced acute lung injury via inhibiting NF-κB and activating Nrf2 signaling pathways. Oncotarget. 2017 Apr 4;8(14):22835-22841

[7]Liu X, Li J, Peng X, Lv B, Wang P, Zhao X, Yu B. Geraniin Inhibits LPS-Induced THP-1 Macrophages Switching to M1 Phenotype via SOCS1/NF-κB Pathway. Inflammation. 2016 Aug;39(4):1421-33

[8]Chung APYS, Gurtu S, Chakravarthi S, Moorthy M, Palanisamy UD. Geraniin Protects High-Fat Diet-Induced Oxidative Stress in Sprague Dawley Rats. Front Nutr. 2018 Mar 16;5:17