Omaveloxolone

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Chemical Structure| 1474034-05-3 同义名 : RTA 408; RTA-408. Omaveloxolone
CAS号 : 1474034-05-3
货号 : A422837
分子式 : C33H44F2N2O3
纯度 : 99%
分子量 : 554.71
MDL号 : MFCD28167769
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(189.29 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 RTA-408 is a synthetic triterpenoid that potently activates the antioxidative transcription factor Nrf2 by binding KEAP1 and inhibits the proinflammatory transcription factor NF-κB.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.80mL

0.36mL

0.18mL

9.01mL

1.80mL

0.90mL

18.03mL

3.61mL

1.80mL
参考文献

[1]Probst BL, Trevino I, et al. RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity. PLoS One. 2015 Apr 21;10(4):e0122942.

[2]Reisman SA, Lee CY, et al. Topical application of the synthetic triterpenoid RTA 408 protects mice from radiation-induced dermatitis. Radiat Res. 2014 May;181(5):512-20.