AEBSF HCl

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Chemical Structure| 30827-99-7 同义名 : AEBSF盐酸盐 ;AEBSF (hydrochloride); AEBSF HCl; Pefabloc SC
CAS号 : 30827-99-7
货号 : A395798
分子式 : C8H11ClFNO2S
纯度 : 98%
分子量 : 239.69
MDL号 : MFCD00132962
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(438.06 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(417.2 mM)
生物活性
描述 AEBSF directly inhibits β-secretase, thereby suppressing the constant production of Aβ across five diverse human cell lines, including both neural and non-neural types[1]. As a serine protease inhibitor, AEBSF prevents the lysis of leukemic cells by human macrophages without affecting the macrophage release of TNF-α and IL-1β[2]. AEBSF disrupts blastocyst development on endometrial cells and impedes the adhesion of HeLa cells to HUVECs by modifying the pattern of protein secretion[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.17mL

0.83mL

0.42mL

20.86mL

4.17mL

2.09mL

41.72mL

8.34mL

4.17mL
参考文献

[1]Citron M, et al. Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF. Neuron. 1996 Jul;17(1):171-9

[2]Nakabo Y, et al. Lysis of leukemic cells by human macrophages: inhibition by 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor. J Leukoc Biol. 1996 Sep;60(3):328-36.

[3]Buitrago-Rey R, et al. Evaluation of two inhibitors of invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane phosphonic acid] and AEBSF [4-(2-aminoethyl)-benzenesulphonyl fluoride] in acute murine toxoplasmosis. J Antimicrob Chemother.

[4]Jiang YH, et al. Serine protease inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) inhibits the rat embryo implantation in vivo and interferes with cell adhesion in vitro. Contraception. 2011 Dec;84(6):642-8.