TEPP-46

产品说明书

Print
Chemical Structure| 1221186-53-3 同义名 : ML-265; CID-44246499; NCGC00186528
CAS号 : 1221186-53-3
货号 : A388355
分子式 : C17H16N4O2S2
纯度 : 99%+
分子量 : 372.46
MDL号 : MFCD23160747
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(134.24 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 TEPP-46 (ML-265) is an effective and specific activator of pyruvate kinase M2 (PKM2), demonstrating an AC50 of 92 nM, while showing minimal to no impact on PKM1, PKL, and PKR[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.68mL

0.54mL

0.27mL

13.42mL

2.68mL

1.34mL

26.85mL

5.37mL

2.68mL
参考文献

[1]Anastasiou D, et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol. 2012 Oct;8(10):839-847.

[2]Palsson-McDermott EM, et al. Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab. 2015 Jan 6;21(1):65-80.