Geniposide
产品说明书
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同义名 : | 栀子苷 |
| CAS号 : | 24512-63-8 | |
| 货号 : | A383596 | |
| 分子式 : | C17H24O10 | |
| 纯度 : | 99+% | |
| 分子量 : | 388.37 | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(270.36 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 50 mg/mL(128.74 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Geniposide (GEN), a kind of iridoid glycoside extracted from Gardenia jasminoides fruit, has many biological effects, such as resistance to cell damage and anti-neurodegenerative disorder. GEN has protective effect on lipid accumulation via enhancing the ability of antioxidative stress and anti-inflammation which were mostly depend on up-regulating the protein expression of Nrf2/HO-1 (nuclear factor erythroid-2-related factor 2/haeme oxygenase) and AMPK (adenosine 5'-monophosphate-activated protein kinase) signalling pathways, thereby suppressed the phosphorylation of mTORC (mechanistic target of rapamycin complex) and its related protein[3]. Moreover, geniposide (10, 20 and 40 mg/kg) could significantly ameliorate acute kidney injury in CLP (cecal ligation and puncture)-induced septic mice and LPS-stimulated HK-2 cells by activating PPARγ[4]. Geniposide was able to increase autophagy and inhibit apoptosis by regulating the function of mTOR in treating Alzheimer's disease. Geniposide has also been shown to act as a glucagon-like peptide-1 receptor (GLP-1R) agonist to reduce amyloid plaques and inhibit oxidative stress to alleviate memory impairment as well as synaptic loss[5]. Geniposide could inhibit the progression of and stabilize atherosclerotic plaques in rabbits by suppressing M1 macrophage polarization and promoting M2 polarization through the FOS/MAPK signaling pathway[6]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.57mL 0.51mL 0.26mL |
12.87mL 2.57mL 1.29mL |
25.75mL 5.15mL 2.57mL |
| 参考文献 |
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