PCO371
产品说明书
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同义名 : | - |
| CAS号 : | 1613373-33-3 | |
| 货号 : | A362704 | |
| 分子式 : | C29H32F3N5O6S | |
| 纯度 : | 98%+ | |
| 分子量 : | 635.65 | |
| MDL号 : | MFCD31657324 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(165.18 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | PCO371, an oral agonist fully targeting PTHR1, does not interact with the PTH type 2 receptor. It prompts cAMP production with an EC50 of 2.4 μM in COS-7 cells with hPTHR1 and 2.5 μM in COS-7 cells with hPTHR1-delNT. Additionally, PCO371 increases phospholipase C activity, with an EC50 of 17 μM[1]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02475616 | Healthy | Phase 1 | Terminated | - | United States, California ... 展开 >> Wcct Global Cypress, California, United States 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.57mL 0.31mL 0.16mL |
7.87mL 1.57mL 0.79mL |
15.73mL 3.15mL 1.57mL |
| 参考文献 |
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