Salicylanilide

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Chemical Structure| 87-17-2 同义名 : 2-羟基-N-苯基苯甲酰胺 ;2-Hydroxybenzanilide
CAS号 : 87-17-2
货号 : A360596
分子式 : C13H11NO2
纯度 : 95%
分子量 : 213.23
MDL号 : MFCD00002212
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 165 mg/mL(773.81 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Salicylanilide demonstrates a wide range of biological activities including antiviral potency which can inhibit HIV virus by targeting HIV-1 integrase or reverse transcriptase[3]. Salicylanilide derivatives substituted by halogens on both salicyl and aniline rings showed better activity, than 4-benzoylaniline derivatives. The ester or carbamate bond formation of parent salicylanilides mostly retained or improved antimycobacterial potency with moderate selectivity[4]. Salicylanilide was excreted unchanged (56%) with small amounts of the 5-hydroxy and 4'-hydroxy-derivatives[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.69mL

0.94mL

0.47mL

23.45mL

4.69mL

2.34mL

46.90mL

9.38mL

4.69mL
参考文献

[1]Kratký M, Vinšova J. Antiviral activity of substituted salicylanilides--a review. Mini Rev Med Chem. 2011 Oct;11(11):956-67.

[2]Kratký M, Vinsova J. Salicylanilide ester prodrugs as potential antimicrobial agents--a review. Curr Pharm Des. 2011;17(32):3494-505.

[3]Krátký M, Vinšová J. Antiviral activity of substituted salicylanilides--a review. Mini Rev Med Chem. 2011 Oct;11(11):956-67

[4]Baranyai Z, Krátký M, Vinšová J, Szabó N, Senoner Z, Horváti K, Stolaříková J, Dávid S, Bősze S. Combating highly resistant emerging pathogen Mycobacterium abscessus and Mycobacterium tuberculosis with novel salicylanilide esters and carbamates. Eur J Med Chem. 2015 Aug 28;101:692-704

[5]Mitchell SC, Norbury HM, Waring RH, Gadsden PM, Wood PB. A comparison of the metabolism and elimination of benzanilide and salicylanilide in the rat. Xenobiotica. 1982 Feb;12(2):93-9