Cyclic AMP
产品说明书
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同义名 : | 腺苷-3'，5'-环磷酸 ;Cyclic adenosine monophosphate; Adenosine cyclic 3',5'-monophosphate; NSC 143670; NSC 94017; Adenosine Cyclophosphate; cAMP |
| CAS号 : | 60-92-4 | |
| 货号 : | A353547 | |
| 分子式 : | C10H12N5O6P | |
| 纯度 : | 99% | |
| 分子量 : | 329.21 | |
| MDL号 : | MFCD00005845 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
H2O: 2 mg/mL(6.08 mM)，配合低频超声助溶 0.1 M NaOH: 30 mg/mL(91.13 mM)，配合低频超声，并调节pH至6 |
| 生物活性 | |||
|---|---|---|---|
| 描述 | cAMP (Cyclic adenosine monophosphate) is the first discovered second messenger, which plays pivotal roles in cell signaling, and regulates many physiological and pathological processes. cAMP can regulate the transcription of various target genes, mainly through protein kinase A (PKA) and its downstream effectors such as cAMP-responsive element binding protein (CREB). cAMP signaling may have both tumor-suppressive and tumor-promoting roles depending on the tumor types and context. cAMP-PKA signaling can regulate cancer cell growth, migration, invasion and metabolism[1]. The second messenger cyclic AMP (cAMP) is a major intracellular mediator of many hormones and neurotransmitters and regulates a myriad of cell functions, including synaptic plasticity in neurons[2]. cAMP critically modulates the development of neuronal connectivity. It is involved in a wide range of cellular processes that require independent regulation. The subcellular compartmentalization and temporal regulation of cAMP signals have recently been identified as important coding strategies leading to specificity[3]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00008008 | Brain and Central Nervous Syst... 展开 >>em Tumors 收起 << | Phase 2 | Completed | - | United States, New Jersey ... 展开 >> St. Joseph's Hospital and Medical Center Paterson, New Jersey, United States, 07503 United States, New York Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center New York, New York, United States, 10032 收起 << |
| NCT02620878 | Type 1 Diabetes | Not Applicable | Completed | - | - |
| NCT01621776 | Type 1 Diabetes | Not Applicable | Completed | - | United States, Florida ... 展开 >> Camp Winona DeLeon Springs, Florida, United States, 32130 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.04mL 0.61mL 0.30mL |
15.19mL 3.04mL 1.52mL |
30.38mL 6.08mL 3.04mL |
| 参考文献 |
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