Arecaidine

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Chemical Structure| 499-04-7 同义名 : Arecaidine But-2-Ynyl Ester Tosylate
CAS号 : 499-04-7
货号 : A347338
分子式 : C7H11NO2
纯度 : 99%+
分子量 : 141.17
MDL号 : MFCD00985225
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 250 mg/mL(1770.94 mM)，配合低频超声助溶
生物活性
描述 Arecaidine but-2-ynyl ester tosylate is a potent muscarinic agonist that shows 4.6-fold that is selectivity for mAChR M2 in the atrium versus those in the ileum.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

7.08mL

1.42mL

0.71mL

35.42mL

7.08mL

3.54mL

70.84mL

14.17mL

7.08mL
参考文献

[1]Moser U, Lambrecht G, et al. Structure-activity relationships of new analogues of arecaidine propargyl ester at muscarinic M1 and M2 receptor subtypes. Br J Pharmacol. 1989 Feb;96(2):319-24.

[2]Barlow RB, Weston-Smith P. The relative potencies of some agonists at M2 muscarinic receptors in guinea-pig ileum, atria and bronchi. Br J Pharmacol. 1985 Jun;85(2):437-40.