CFI-400945

产品说明书

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Chemical Structure| 1338806-73-7 同义名 : -
CAS号 : 1338806-73-7
货号 : A335666
分子式 : C33H34N4O3
纯度 : 98%
分子量 : 534.65
MDL号 : MFCD28386170
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
靶点

  • PLK4

    PLK4, IC50:2.8 nM
描述 CFI400945 is a potent and selective,orally bioavailable PLK4 inhibitor with an IC50 value of 2.8 ±1.4 nM have potential antineoplastic activity.
细胞研究
细胞系 浓度 检测类型 检测时间 活性说明 数据源
A549 cells Growth inhibition assay 5 days Growth inhibition of human A549 cells after 5 days by SRB assay, GI50=0.005 μM 25723005
HCC1954 cells Growth inhibition assay 5 days Growth inhibition of human HCC1954 cells after 5 days by SRB assay, GI50=5 nM 25723005
HMEC cells Growth inhibition assay 5 days Growth inhibition of human HMEC cells after 5 days by SRB assay, GI50=9 μM 25723005
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.87mL

0.37mL

0.19mL

9.35mL

1.87mL

0.94mL

18.70mL

3.74mL

1.87mL
参考文献

[1]Mason JM et al. Functional characterization of CFI-400945, a Polo-like kinase 4 inhibitor, as a potential anticancer agent. Cancer Cell. 2014 Aug 11;26(2):163-76.