NP-313

产品说明书

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Chemical Structure| 5397-78-4 同义名 : -
CAS号 : 5397-78-4
货号 : A332493
分子式 : C12H8ClNO3
纯度 : 95%
分子量 : 249.65
MDL号 : MFCD00091844
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(100.14 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 NP-313 is a powerful antithrombotic compound that effectively suppresses platelet aggregation and activation. It achieves its effects through dual inhibition of thromboxane A2 synthesis and selective suppression of SOCC-mediated Ca2+ inward flow[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.01mL

0.80mL

0.40mL

20.03mL

4.01mL

2.00mL

40.06mL

8.01mL

4.01mL
参考文献

[1]Heng-Lan Kuo, et al. NP-313, 2-acetylamino-3-chloro-1,4-naphthoquinone, a novel antithrombotic agent with dual inhibition of thromboxane A(2) synthesis and calcium entry. Br J Pharmacol. 2011 Apr;162(8):1871-83.