Triclosan

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Chemical Structure| 3380-34-5 同义名 : Irgasan; Cloxifenolum
CAS号 : 3380-34-5
货号 : A325018
分子式 : C12H7Cl3O2
纯度 : 95%
分子量 : 289.54
MDL号 : MFCD00800992
存储条件：

Pure form Inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(362.64 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Triclosan is an antibacterial and antifungal agent found in consumer products, including soaps, detergents, toys, and surgical cleaning treatments. Triclosan is readily absorbed into human skin and oral mucosa and found in various human tissues and fluids[3]. Triclosan, on the other hand, significantly affected bacterial diversity and community structure. Genera harboring opportunistic pathogens such as Flavobacterium were enriched in the presence of triclosan, as was Stenotrophomonas[4]. In addition, Triclosan can inhibit InhA, an essential enoyl acyl carrier protein reductase, resulting in the lysis of Mycobacterium tuberculosis[5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02437578 - Active, not recruiting April 2019 Denmark ... 展开 >> Dansk Fertilitetsklinik Frederiksberg, Denmark, 2000 收起 <<
NCT01778868 - Unknown July 2013 Belgium ... 展开 >> University Hospital Antwerp Edegem, Antwerpen, Belgium, 2650 收起 <<
NCT00631566 HIV Infections ... 展开 >> Staphylococcal Infections 收起 << Not Applicable Completed - United States, California ... 展开 >> Naval Medical Center San Diego/Infectious Disease Division San Diego, California, United States, 92134-1201 United States, Maryland Walter Reed National Military Medical Center Bethesda, Maryland, United States, 20889 United States, Texas San Antonio Military Medical Center (BAMC/WHMC) San Antonio, Texas, United States, 78236-9908 United States, Virginia Naval Medical Center Portsmouth Portsmouth, Virginia, United States, 23708-2197 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.45mL

0.69mL

0.35mL

17.27mL

3.45mL

1.73mL

34.54mL

6.91mL

3.45mL
参考文献

[1]Yueh MF, Taniguchi K, et al. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17200-5.

[2]Winitthana T, Lawanprasert S, Chanvorachote P. Triclosan potentiates epithelial-to-mesenchymal transition in anoikis-resistant human lung cancer cells. PLoS One. 2014 Oct 16;9(10):e110851.

[3]Weatherly LM, Gosse JA. Triclosan exposure, transformation, and human health effects. J Toxicol Environ Health B Crit Rev. 2017;20(8):447–469

[4]Phandanouvong-Lozano V, Sun W, Sanders JM, Hay AG. Biochar does not attenuate triclosan's impact on soil bacterial communities. Chemosphere. 2018;213:215–225

[5]Vosátka R, Krátký M, Vinšová J. Triclosan and its derivatives as antimycobacterial active agents. Eur J Pharm Sci. 2018;114:318–331