Paxilline
产品说明书
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同义名 : | - |
| CAS号 : | 57186-25-1 | |
| 货号 : | A294941 | |
| 分子式 : | C27H33NO4 | |
| 纯度 : | 98% | |
| 分子量 : | 435.56 | |
| MDL号 : | MFCD00083464 | |
| 存储条件： |
Pure form Keep in dark place, sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(241.07 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Paxilline is a toxic, tremorgenic diterpene indole polycyclic alkaloid molecule produced by Penicillium paxilli. It works as BK channels inhibitor and SERCA inhibitor. It had anticonvulsant activity against picrotoxin and pentylenetetrazol seizures in mice[1]. It has also been used in mice to induce autism-like behaviors through inhibition of the BK channel[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.30mL 0.46mL 0.23mL |
11.48mL 2.30mL 1.15mL |
22.96mL 4.59mL 2.30mL |
| 参考文献 |
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