Human LAG-3 (C-6His, HEK293)(Leu23-Gly434)
产品说明书
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同义名 : | 重组人LAG-3蛋白(C-6His, HEK293)(Leu23-Gly434) ;Recombinant Human LAG-3 (C-6His, HEK293)(Leu23-Gly434); Lymphocyte activation gene 3 protein; LAG3; LAG-3; Protein FDC; CD223 |
| CAS号 : | N/A | |
| 货号 : | A2926626 | |
| 分子式 : | - | |
| 纯度 : | 95% determined by reducing SDS-PAGE. | |
| 分子量 : | 45.5 KDa | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4. | ||