Human CDCP1 (C-6His, HEK293)(Phe30-Ser341)
产品说明书
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同义名 : | 重组人CDCP1蛋白(C-6His, HEK293)(Phe30-Ser341) ;Recombinant Human CDCP1 (C-6His, HEK293)(Phe30-Ser341); CUB domain-containing protein 1; Membrane glycoprotein gp140; Subtractive immunization M plus HEp3-associated 135 kDa protein; SIMA135; Transmembrane and associated with src kinases; CD318; TRASK |
| CAS号 : | N/A | |
| 货号 : | A2926621 | |
| 分子式 : | - | |
| 纯度 : | 85% determined by reducing SDS-PAGE. | |
| 分子量 : | 36.1 KDa | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
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| 描述 | CUB domain-containing protein 1(CDCP1) is a transmembrane glycoprotein with a large extracellular domain (ECD) containing two CUB domains, and a smaller intracellular domain (ICD) containing five tyrosines. CDCP1 is widely expressed in human epithelial tissues, but its phosphorylation is only seen in mitotically detached or shedding cells, consistent with its role in the negative regulation of cell adhesion. The tyrosine phosphorylation of CDCP1 in cultured cells occurs when cells are induced to detach by trypsinor EDTA, or seen spontaneously during mitotic detachment. The overexpression of CDCP1 leads to the loss of cell adhesion and a detached phenotype. | ||