| 描述 |
CD37 is a member of the transmembrane 4 superfamily (TM4SF) of tetraspanin proteins. It consists of four potential membrane-spanning regions, two extracellular loops and short intracytoplasmatic tails. CD37 is expressed on developing B-cells from pre-B, peripheral mature B-cell stages, but not plasma cells. The involvement of CD37 (TSPAN26) protein in various biological processes including cell adhesion, motility, differentiation, proliferation, metastasis, growth, survival, trafficking, intercellular communication via exosomes and immune responses is well recognized. |