Human B7-H3 (2Ig, C-Fc, HEK293)
产品说明书
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同义名 : | 重组人B7-H3蛋白(2Ig, C-Fc, HEK293) ;Recombinant Human B7-H3 (2Ig, C-Fc, HEK293); CD276; 2Ig-B7-H3; B7-H3; B7 homolog 3; CD276 antigen; CD276 molecule; Costimulatory molecule |
| CAS号 : | N/A | |
| 货号 : | A2926411 | |
| 分子式 : | - | |
| 纯度 : | 95% determined by reducing SDS-PAGE. | |
| 分子量 : | 50.2 KDa | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
|---|---|---|---|
| 描述 | CD276, also known as B7-H3, is a member of the B7 superfamily with signature IgV and IgG regions in extracellular domains. It is also reported that B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is expressed on T-cells, natural killer cells, and antigen presenting cells, as well as some non-immune cells, such as osteoblasts, fibroblasts, fibroblast-like synoviocytes and epithelial cells. High expression of B7-H3 in tumor vasculature also correlates with poor survival in patients, suggesting that it may play a role in tumor cell migration. In humans, the B7-H3 gene has four Ig-like repeats that can be alternatively spliced to yield a protein containing either four Ig-like (4Ig) or two Ig-like (2Ig) domains, whereas the mouse gene only contains two Ig-like repeats and thus, only one form (2Ig) is generated. Systemic genomic analysis suggested that the 4Ig form, with two copies of IgV-IgC domain, was generated from tandem exon duplication during evolution of the immune system. | ||