Biotinylated Human Latent TGF-beta 3 (N-8His-Avi, HEK293)
产品说明书
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同义名 : | 重组生物素化人Latent TGF-beta 3蛋白(N-8His-Avi, HEK293) ;Biotinylated Human Latent TGF-beta 3 (N-8His-Avi, HEK293); Transforming growth factor beta-3 proprotein; TGF-beta-3; TGFβ3; TGFB3 |
| CAS号 : | N/A | |
| 货号 : | A2926272 | |
| 分子式 : | - | |
| 纯度 : | 90% determined by reducing SDS-PAGE. | |
| 分子量 : | 12.7&35.3 KDa | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Transforming growth factor beta (TGFβ) is a multifunctional cytokine that regulates cell growth, differentiation, adhesion, migration and death dependent on cell type, developmental stage, or tissue conditions. There are three isoforms of TGFβ (TGFβ-1, -2 and -3). TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3. TGF-beta 3 binds with high affinity to TGF-beta RII, a type II serine/threonine kinase receptor. This receptor then phosphorylates and activates type I serine/threonine kinase receptors, TGF-beta RI or ALK-1, to modulate transcription through Smad phosphorylation. | ||