Human FcAR (C-6His, HEK293)

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Chemical Structure| N/A 同义名 : 重组人FcAR蛋白(C-6His, HEK293) ;Recombinant Human FcAR (C-6His, HEK293); Immunoglobulin Alpha Fc Receptor; IgA Fc Receptor; CD89; FCAR
CAS号 : N/A
货号 : A2924432
分子式 : -
纯度 : 95% determined by reducing SDS-PAGE.
分子量 : 24.52 KDa
MDL号 : -
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 Immunoglobulin α Fc Receptor (IgA Fc Receptor) is a member of the immunoglobulin gene superfamily. It is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens through the charged arginin residue within its transmembrane domain. IgA Fc Receptor binds both IgA1 and IgA2 with similar affinity. The site of interaction between FCAR and IgA was identified in the first extracellular domain of FCAR and the C2/C3 junction of IgA. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. FCAR is also expressed on Kupffer cells in the liver, where it was suggested to provide a second line of defense.