Human PFKFB3 (N-6His)
产品说明书
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同义名 : | 重组人PFKFB3蛋白(E.coli, N-6His) ;Recombinant Human PFKFB3 (N-6His) |
| CAS号 : | N/A | |
| 货号 : | A2900908 | |
| 分子式 : | - | |
| 纯度 : | 95% >=95% as determined by reducing SDS-PAGE. | |
| 分子量 : | 0 | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -70°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | 产品名称：Recombinant Human PFKFB3 (N-6His)理论分子量：61.8 KDa蛋白种属：Human表达系统：E.coli蛋白表达区间：Met1-His520标签：N-6His剂型：液体纯度：≥95% as determined by reducing SDS-PAGE.储存条件：储存温度≤-70°C，收到后可稳定保存6个月。 储存于≤-70°C，开封后在无菌条件下可稳定保存3个月。 开封后请按照用量分装，尽量减少反复冻融次数。产品背景：Fructose-2,6-biphosphatase 3, also known as 6-phosphofructo-2-kinase or PFK2 or PFKFB3, involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls the activity of the enzymes phosphofructokinase 1 (PFK-1) and fructose 1,6-bisphosphatase (FBPase-1) to regulate glycolysis and gluconeogenesis. Highly phosphorylated PFKFB3 protein was found in human tumor cells, vascular endothelial cells, and smooth muscle cells. Because of its proto-oncogenic character, the PFK-2/FBPase-2 of the PFKFB3 gene is assumed to play a critical role in tumorigenesis. PFKFB3 also plays a crucial role in the progression of cancerous cells by enabling their glycolytic pathways even under severe hypoxic conditions, which makes it a potential target for cancer therapy. | ||