Human UBE2M
产品说明书
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同义名 : | 重组人UBE2M蛋白(E.coli, tag free) ;Recombinant Human UBE2M |
| CAS号 : | N/A | |
| 货号 : | A2900876 | |
| 分子式 : | - | |
| 纯度 : | 95% >=95% as determined by reducing SDS-PAGE. | |
| 分子量 : | 0 | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -70°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | 产品名称：Recombinant Human UBE2M理论分子量：20.9 KDa蛋白种属：Human表达系统：E.coli蛋白表达区间：Met1-Lys183标签：Tag free剂型：液体纯度：≥95% as determined by reducing SDS-PAGE.储存条件：储存温度≤-70°C，收到后可稳定保存6个月。 储存于≤-70°C，开封后在无菌条件下可稳定保存3个月。 开封后请按照用量分装，尽量减少反复冻融次数。产品背景：UBE2M is a member of the E2 ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. UBE2M accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. It involved in cell proliferation and is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. | ||