Human C8 gamma (N-6His)
产品说明书
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同义名 : | 重组人C8 gamma蛋白(E.coli, N-6His) ;Recombinant Human C8 gamma (N-6His); Complement component C8 gamma chain; C8G |
| CAS号 : | N/A | |
| 货号 : | A2900719 | |
| 分子式 : | - | |
| 纯度 : | 95% determined by SDS-PAGE. | |
| 分子量 : | 22.6 KDa | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -70°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Complement component C8 is a constituent of the membrane attack complex, C8 alpha, C8 beta and C8G. C8G is a secreted protein and comsists a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 alpha and C8 beta play an important role in complement-mediated bacterial killing together.C8 is involved in the formation of Membrane Attack Complex on bacterial cell membranes. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. Patients lacking C8 are susceptible to certain bacterial infections. | ||