Human CDK2 (N-6His)
产品说明书
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同义名 : | 重组人CDK2蛋白(E.coli, N-6His) ;Recombinant Human CDK2 (N-6His); Cyclin-Dependent Kinase 2; Cell Division Protein Kinase 2; p33 Protein Kinase; CDK2; CDKN2 |
| CAS号 : | N/A | |
| 货号 : | A2900712 | |
| 分子式 : | - | |
| 纯度 : | 90% >=90% as determined by reducing SDS-PAGE. | |
| 分子量 : | 36.1 KDa | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -70°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
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| 描述 | 产品名称：Recombinant Human CDK2 (N-6His)理论分子量：36.1 KDa蛋白种属：Human表达系统：E.coli蛋白表达区间：Met1-Leu298标签：N-6His剂型：液体纯度：≥90% as determined by reducing SDS-PAGE.储存条件：储存温度≤-70°C，收到后可稳定保存6个月。 储存于≤-70°C，开封后在无菌条件下可稳定保存3个月。 开封后请按照用量分装，尽量减少反复冻融次数。产品背景：Cyclin-dependent kinase 2 (CDK2) belongs to the cyclin-dependent kinase of Ser/Thr protein kinase. CDK2 acts as a catalytic subunit of the cyclin dependent kinase complex, whose activity is restricted to the G1-S phage of the cell cycle, it is essential for the G1/S transition. The kinase activity of CDK2 can be regulated by the association with a cyclin subunit, its phosphorylation state and CDK inhibitors. The activation of the CDK2/cyclin complex requires the phosphorylation of Thr160 and the dephosphorylation of Try14 and Tyr15. The inhibition of CDK2-cyclin complex can also be attributed to association with p27Kip1 and p21Waf1/Cip1. The activation of CDK2 has been shown to be necessary for apoptosis of quiescent cells, such as neurons, thymocytes and endothelial cells. | ||