Azomycin
产品说明书
 |
同义名 : | 2-硝基咪唑 ;2-Nitroimidazole |
| CAS号 : | 527-73-1 | |
| 货号 : | A259140 | |
| 分子式 : | C3H3N3O2 | |
| 纯度 : | 99% | |
| 分子量 : | 113.07 | |
| MDL号 : | MFCD00005185 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 50 mg/mL(442.19 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Azomycin (2-Nitroimidazole) is an antibiotic which can be active against aerobic Gram-positive and Gram-negative bacteria[1]. Azomycin and the 5-nitroimidazole ronidazole did not bind to any G. lamblia proteins, which is in contrast to previous findings in E. histolytica and T. vaginalis. All nitroimidazoles tested reduced intracellular thiol pools in G. lamblia[2]. The biosynthetic gene cluster for azomycin is widely distributed among soil-dwelling actinobacteria and proteobacteria, suggesting that azomycin and related nitroimidazoles may play important ecological roles[3]. Azomycin capsule is bioequivalent to Zithromax capsule and Azomycin suspension is bioequivalent to Zithromax suspension[4]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01055678 | Breast Cancer | Early Phase 1 | Withdrawn(PI left Duke) | - | United States, North Carolina ... 展开 >> Duke University Medical Center Durham, North Carolina, United States, 27710 收起 << |
| NCT01995084 | Pancreatic Cancer ... 展开 >> Esophageal Cancer Rectal Cancer 收起 << | Not Applicable | Completed | - | Netherlands ... 展开 >> Academic Medical Center Amsterdam, Netherlands, 1105AZ 收起 << |
| NCT00430079 | Adult Anaplastic Astrocytoma ... 展开 >> Adult Anaplastic Ependymoma Adult Anaplastic Oligodendroglioma Adult Diffuse Astrocytoma Adult Ependymoma Adult Giant Cell Glioblastoma Adult Glioblastoma Adult Gliosarcoma Adult Mixed Glioma Adult Myxopapillary Ependymoma Adult Oligodendroglioma Adult Pilocytic Astrocytoma Adult Pineal Gland Astrocytoma Adult Subependymoma 收起 << | Not Applicable | Terminated(Administratively co... 展开 >>mplete.) 收起 << | - | United States, Pennsylvania ... 展开 >> Abramson Cancer Center of The University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
8.84mL 1.77mL 0.88mL |
44.22mL 8.84mL 4.42mL |
88.44mL 17.69mL 8.84mL |
| 参考文献 |
|---|