Spironolactone

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Chemical Structure| 52-01-7 同义名 : 安体舒通 ;SC9420; NSC 150399; Spiridon; Spiresis
CAS号 : 52-01-7
货号 : A243260
分子式 : C24H32O4S
纯度 : 98+%
分子量 : 416.57
MDL号 : MFCD00082250
存储条件：

Pure form Keep in dark place, sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(120.03 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • Androgen Receptor

    Androgen Receptor, IC50:77 nM
描述 Spironolactone is a potent antagonist of the androgen receptor with IC50 of 77 nM.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01944384 Diastolic Heart Failure Phase 4 Completed - -
NCT00123955 Diastolic Heart Failure ... 展开 >> Heart Failure, Congestive 收起 << Phase 3 Completed - United States, North Carolina ... 展开 >> Wake Forest University Baptist Medical Center Winston-Salem, North Carolina, United States, 27157 收起 <<
NCT00123955 - Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.40mL

0.48mL

0.24mL

12.00mL

2.40mL

1.20mL

24.01mL

4.80mL

2.40mL
参考文献

[1]Fagart J, Hillisch A, et al. A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule. J Biol Chem. 2010 Sep 24;285(39):29932-40.

[2]Bonne C, Raynaud JP. Mode of spironolactone anti-androgenic action: inhibition of androstanolone binding to rat prostate androgen receptor. Mol Cell Endocrinol. 1974 Dec;2(1):59-67.