Tamoxifen

产品说明书

Print
Chemical Structure| 10540-29-1 同义名 : ICI 47699; trans-Tamoxifen; ICI 46474; (Z)-Tamoxifen
CAS号 : 10540-29-1
货号 : A210874
分子式 : C26H29NO
纯度 : 97%
分子量 : 371.51
MDL号 : MFCD00010454
存储条件：

Pure form

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(67.29 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 50 mg/mL(134.58 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方：
生物活性
靶点

  • Estrogen receptor
描述 Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen.
细胞研究
细胞系 浓度 检测类型 检测时间 活性说明 数据源
518A2 cells Cytotoxicity assay 96 h Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay, IC50=7.62 μM 22749392
850C cells Cytotoxicity assay 96 h Cytotoxicity against human 850C cells after 96 hrs by SRB assay, IC50=11.09 μM 22749392
A253 cells Cytotoxicity assay 96 h Cytotoxicity against human A253 cells after 96 hrs by SRB assay, IC50=8.92 μM 22749392
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00041080 Fallopian Tube Cancer ... 展开 >> Primary Peritoneal Cavity Cancer Recurrent Ovarian Epithelial Cancer Stage III Ovarian Epithelial Cancer Stage IV Ovarian Epithelial Cancer 收起 << Phase 3 Completed - United States, Pennsylvania ... 展开 >> Gynecologic Oncology Group Philadelphia, Pennsylvania, United States, 19103 收起 <<
NCT00041080 - Completed - -
NCT03011684 Infertility Phase 3 Recruiting December 2019 United States, California ... 展开 >> University of California at San Francisco Recruiting San Francisco, California, United States, 94143 Contact: Mitchell Rosen, M.D.       Mitchell.Rosen@ucsf.edu    Contact: Joseph Letourneau       joseph.letourneau@ucsf.edu    Principal Investigator: Mitchell Rosen, M.D. 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.69mL

0.54mL

0.27mL

13.46mL

2.69mL

1.35mL

26.92mL

5.38mL

2.69mL