Spectinomycin 2HCl pentahydrate
产品说明书
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同义名 : | Spectinomycin hydrochloride hydrate; Spectinomycin (hydrochloride hydrate); Trobicin |
| CAS号 : | 22189-32-8 | |
| 货号 : | A206958 | |
| 分子式 : | C14H36Cl2N2O12 | |
| 纯度 : | 95% | |
| 分子量 : | 495.35 | |
| MDL号 : | MFCD00150886 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
H2O: 60 mg/mL(121.13 mM)，配合低频超声助溶 |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Spectinomycin (Dihydrochloride Pentahydrate) is a broad-spectrum aminocyclitol antibiotic that is highly effective in the treatment of uncomplicated gonorrhea. It is a good alternative drug in the treatment of penicillin-allergic patients[3]. Aminomethyl spectinomycins are active against Gram-negative and Gram-positive bacterial pathogens. Aminomethyl spectinomycins are promising new candidates for development of therapeutics against biodefense bacterial agents[4]. Spectinomycin selectively inhibits protein synthesis in cells and in extracts of Escherichia coli. However, spectinomycin is not bactericidal and causes no detectable misreading of polyribonucleotides[5]. The kinetic analysis demonstrated that spectinomycin acts as a mixed noncompetitive inhibitor for the td (T4 thymidylate synthase gene) intron RNA with a K(i) of 7.2 mM. Increasing the spectinomycin concentration raised the K(m) values with the corresponding decrease of V(max) and k(cat) values[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.02mL 0.40mL 0.20mL |
10.09mL 2.02mL 1.01mL |
20.19mL 4.04mL 2.02mL |
| 参考文献 |
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[3]Holloway WJ. Spectinomycin. Med Clin North Am. 1982;66(1):169–173 |