EHop-016

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Chemical Structure| 1380432-32-5 同义名 : -
CAS号 : 1380432-32-5
货号 : A206639
分子式 : C25H30N6O
纯度 : 98%
分子量 : 430.55
MDL号 : MFCD23143628
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(69.68 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • Rac

    Rac1, IC50:1.1 μM
描述 EHop-016 is a potent and selective inhibitor of Rac GTPase and inhibits Rac1 activity in MDA-MB-435 cells with an IC50 of 1.1 μM.
细胞研究
细胞系 浓度 检测类型 检测时间 活性说明 数据源
human MDA-MB-435 cells Function assay 24 h Inhibition of Rac1 in human MDA-MB-435 cells after 24 hrs by G-LISA assay, IC50=1.1 μM 24520998
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.32mL

0.46mL

0.23mL

11.61mL

2.32mL

1.16mL

23.23mL

4.65mL

2.32mL
参考文献

[1]Martin H, Mali RS, et al. Pak and Rac GTPases promote oncogenic KIT-induced neoplasms. J Clin Invest. 2013 Oct;123(10):4449-63.

[2]Montalvo-Ortiz BL, Castillo-Pichardo L, et al. Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase. J Biol Chem. 2012 Apr 13;287(16):13228-38.