Citric acid

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Chemical Structure| 77-92-9 同义名 : 无水柠檬酸
CAS号 : 77-92-9
货号 : A198670
分子式 : C6H8O7
纯度 : 98%
分子量 : 192.12
MDL号 : MFCD00011669
存储条件：

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(546.52 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(520.5 mM)，配合低频超声助溶
生物活性
描述 Citric Acid, widely existing in plants and animals, is commonly used in many food products as food additive [1-2] . In vitro studies, it was observed that citric acid had cytotoxicity on murine macrophages, when 15% citric acid was added into the cell culture with 5 x 105murine macrophages [3] . In vivo studies, microinjection of 7.5% citric acid into the larynx could induce a stable cough in guinea pig [4] . Besides this, it was found that citric acid could ameliorate ketosis and diabetic complications in streptozotocin (type 1) diabetic rats [2] .
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.21mL

1.04mL

0.52mL

26.03mL

5.21mL

2.60mL

52.05mL

10.41mL

5.21mL
参考文献

[1]Baş H, Kalender S, Pandir D. In vitro effects of quercetin on oxidative stress mediated in human erythrocytes by benzoic acid and citric acid. Folia Biol (Krakow). 2014;62(1):59-66.

[2]Nagai R, Nagai M, et al. Citric acid inhibits development of cataracts, proteinuria and ketosis in streptozotocin (type 1) diabetic rats. Biochem Biophys Res Commun. 2010;393(1):118-22.

[3]Amaral KF, Rogero MM, et al. Cytotoxicity analysis of EDTA and citric acid applied on murine resident macrophages culture. Int Endod J. 2007;40(5):338-43.

[4]Tanaka M, Kawamoto S, Maruyama K. [Coughing model by microinjection of citric acid into the larynx in guinea pig]. Nihon Yakurigaku Zasshi. 2002;120(4):237-43.