Acebutolol HCl

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Chemical Structure| 34381-68-5 同义名 : 盐酸醋丁酰心安 ;Acebutolol (hydrochloride); M&B 17803A; Acebutolol hydrochloride
CAS号 : 34381-68-5
货号 : A193568
分子式 : C18H29ClN2O4
纯度 : 97+%
分子量 : 372.89
MDL号 : MFCD00078860
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(281.59 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(134.09 mM)
动物实验配方：
生物活性
靶点

  • β-adrenergic receptor
描述 Acebutolol hydrochloride is a β-adrenergic receptors antagonist used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01316952 - Completed - -
NCT00578617 Atrial Fibrillation ... 展开 >> Arrhythmia 收起 << Not Applicable Completed - United States, Alabama ... 展开 >> Universtity of Alabama Hospital Birminham, Alabama, United States, 35233 United States, California Good Samaritan Hospital Los Angeles, California, United States, 90017 United States, Illinois Loyola University Maywood, Illinois, United States, 60626 United States, Iowa Mercy Medical Center Des Moines, Iowa, United States, 50314 United States, Maryland Johns Hopkins Hospital Baltimore, Maryland, United States, 21287 United States, Massachusetts Brigham and Womens Hospital Boston, Massachusetts, United States, 02115 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55902 United States, Ohio Ohio State University Medical Center Columbus, Ohio, United States, 43210 United States, Pennsylvania University of Pennsylvania Health Philadelphia, Pennsylvania, United States, 19104 United States, Utah Intermountain Medical Center Murray, Utah, United States, 84157 收起 <<
NCT00578617 - Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.68mL

0.54mL

0.27mL

13.41mL

2.68mL

1.34mL

26.82mL

5.36mL

2.68mL
参考文献

[1]Seifert T, Zschornig O, et al. Beta-blockers inhibit the modification of low-density lipoproteins by sodium hypochlorite in vitro. Chem Phys Lipids. 1997 Jan 17;85(1):13-21.

[2]Mauriege P, De Pergola G, et al. Human fat cell beta-adrenergic receptors: beta-agonist-dependent lipolytic responses and characterization of beta-adrenergic binding sites on human fat cell membranes with highly selective beta 1-antagonists. J Lipid Res. 1988 May;29(5):587-601.