Picolinic acid

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Chemical Structure| 98-98-6 同义名 : PCL 016
CAS号 : 98-98-6
货号 : A191920
分子式 : C6H5NO2
纯度 : 97%
分子量 : 123.1
MDL号 : MFCD00006293
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(852.9 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(406.14 mM)
动物实验配方：
生物活性
描述 Picolinic acid (PCL 016; PA) is a natural toxic pyridine derivative. Microorganisms can degrade and utilize PA for growth[1]. In contrast to kynurenine and 3-hydroxyanthranilic acid, exposure of T cells with picolinic acid did not affect cell viability, whereas proliferation and metabolic activity were suppressed in a dose-dependent manner. Picolinic acid mediates a unique immunosuppressive program in T cells, mainly inhibiting cell cycle and metabolic activity, while leaving other effector functions intact[2]. PIC (Picolinic acid) significantly decreased the electroconvulsive threshold and, after intracerebroventricular injection, but not subcutaneous, produced convulsions. Of the studied convulsants, only the activity of pilocarpine hydrochloride was significantly enhanced by PIC[3]. Furthermore, picolinic acid may affect NO2- production via both TNF-alpha-dependent and TNF-alpha-independent pathways[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

8.12mL

1.62mL

0.81mL

40.62mL

8.12mL

4.06mL

81.23mL

16.25mL

8.12mL
参考文献

[1]Qiu J, Zhao L, Xu S, Chen Q, Chen L, Liu B, Hong Q, Lu Z, He J. Identification and Characterization of a Novel pic Gene Cluster Responsible for Picolinic Acid Degradation in Alcaligenes faecalis JQ135. J Bacteriol. 2019 Jul 24;201(16):e00077-19

[2]Prodinger J, Loacker LJ, Schmidt RL, Ratzinger F, Greiner G, Witzeneder N, Hoermann G, Jutz S, Pickl WF, Steinberger P, Marculescu R, Schmetterer KG. The tryptophan metabolite picolinic acid suppresses proliferation and metabolic activity of CD4+ T cells and inhibits c-Myc activation. J Leukoc Biol. 2016 Apr;99(4):583-94

[3]Cioczek-Czuczwar A, Czuczwar P, Turski WA, Parada-Turska J. Influence of picolinic acid on seizure susceptibility in mice. Pharmacol Rep. 2017 Feb;69(1):77-80

[4]Melillo G, Cox GW, Radzioch D, Varesio L. Picolinic acid, a catabolite of L-tryptophan, is a costimulus for the induction of reactive nitrogen intermediate production in murine macrophages. J Immunol. 1993 May 1;150(9):4031-40