FAAH inhibitor 1

产品说明书

Print
Chemical Structure| 326866-17-5 同义名 : Benzothiazole analog 3
CAS号 : 326866-17-5
货号 : A164135
分子式 : C24H23N3O3S3
纯度 : 99%+
分子量 : 497.65
MDL号 : MFCD02167759
存储条件：

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(120.57 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 FAAH inhibitor 1 is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 18±8 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.01mL

0.40mL

0.20mL

10.05mL

2.01mL

1.00mL

20.09mL

4.02mL

2.01mL
参考文献

[1]Wang X, Sarris K, et al. Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors. J Med Chem. 2009 Jan 8;52(1):170-80.

[2]Meyers MJ, Long SA, et al. Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 1: identification of 7-azaspiro[3.5] nonane and 1-oxa-8-azaspiro[4.5] decane as lead scaffolds. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6538-44.