Labetalol HCl

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Chemical Structure| 32780-64-6 同义名 : 柳胺苄心定 ;AH-5158 hydrochloride; Sch-15719W; NSC 290312; AH 5158A; Labetalol (hydrochloride); Labetalol hydrochloride
CAS号 : 32780-64-6
货号 : A155972
分子式 : C19H25ClN2O3
纯度 : 98+%
分子量 : 364.87
MDL号 : MFCD00057663
存储条件：

Pure form Inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(287.78 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 20 mg/mL(54.81 mM)，配合低频超声助溶
生物活性
靶点

  • α-adrenergic receptor
描述 Labetalol hydrochloride is a mixed alpha/beta adrenergic antagonist that is used to treat high blood pressure.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01316952 - Completed - -
NCT02135315 Acute Coronary Syndrome Not Applicable Recruiting December 2017 Tunisia ... 展开 >> university of Monastir Recruiting Monastir, Tunisia, 5000 Contact: Nouirahead of departement    216073532014    semir.nouira@rns.tn    Contact: Fattouma Bourguiba University Hospital    +216 73 106 085    semir.nouira@rns.tn    Principal Investigator: semir nouira, professor 收起 <<
NCT01688648 Unstable Angina ... 展开 >> Coronary Artery Bypass Graft Dexmedetomidine Lidocaine Myocardial Injury Arrhythmia Blood Electrolyte Balance 收起 << Not Applicable Completed - Korea, Republic of ... 展开 >> Samsung Medical Center Seoul, Korea, Republic of, 135-710 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.74mL

0.55mL

0.27mL

13.70mL

2.74mL

1.37mL

27.41mL

5.48mL

2.74mL
参考文献

[1]Garse H, Vij M, et al. Formulation and evaluation of a gastroretentive dosage form of labetalol hydrochloride. Arch Pharm Res. 2010 Mar;33(3):405-10.

[2]Hopkins R, Martin LE, Bland R. The metabolism of labetalol in animals and man. Biochem Soc Trans. 1976;4(4):726-9.