PFI-90

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Chemical Structure| 53995-62-3 同义名 : -
CAS号 : 53995-62-3
货号 : A1534302
分子式 : C11H10N4O
纯度 : 99%+
分子量 : 214.22
MDL号 : MFCD27925103
存储条件：

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(490.14 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • KDM3
描述 PFI-90 exhibits a dose response in RH4, RH30, OSA-CL, and TC-32 cells with IC50 values of 812, 3200, 1895, and 1113 nM, respectively [1]. PFI-90 (3 μM; 24 hours) induces increased apoptosis in RH4 and SCMC cells [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.67mL

0.93mL

0.47mL

23.34mL

4.67mL

2.33mL

46.68mL

9.34mL

4.67mL
参考文献

[1]KHAN, Javed, et al. Inhibitors of histone demethylases (pfi-63 and pfi-90) for the treatment of cancer and for the inhibition of histone demethylase in cells. WO2021101929A1.