NF-κB-IN-1

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Chemical Structure| 1227098-15-8 同义名 : -
CAS号 : 1227098-15-8
货号 : A1448619
分子式 : C31H30O8
纯度 : 99%+
分子量 : 530.57
MDL号 : MFCD29924825
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(94.24 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 NF-κB-IN-1, a 4-arylidene curcumin analogue, serves as a potent inhibitor of the NF-κB signaling pathway. It directly targets IKK to impede NF-κB activation and effectively diminishes the viability of lung cancer cells, while reducing the clonogenic activity of A549 cells [1].
作用机制 NF-κB-IN-1 inhibits NF-κB by inhibiting IκB phosphorylation and degradation via IKK blockage.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.88mL

0.38mL

0.19mL

9.42mL

1.88mL

0.94mL

18.85mL

3.77mL

1.88mL
参考文献

[1]Qiu X, et, al. Synthesis and identification of new 4-arylidene curcumin analogues as potential anticancer agents targeting nuclear factor-κB signaling pathway. J Med Chem. 2010 Dec 9;53(23):8260-73.