Bromfenac sodium

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Chemical Structure| 91714-93-1 同义名 : Bromfenac (sodium salt); AHR 10282B
CAS号 : 91714-93-1
货号 : A142956
分子式 : C15H11BrNNaO3
纯度 : 98%
分子量 : 356.15
MDL号 : MFCD03701673
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 10 mg/mL(28.08 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • COX-1
描述 Bromfenac Sodium is a brominated NSAID (nonsteroidal anti-inflammatory drugs) with strong in vitro anti-inflammatory potency. In rat models of acute (carrageenan paw edema) and chronic (adjuvant arthritis) inflammation, preparations of bromfenac at concentrations as low as 0.01-0.32% (0.01-0.32 mg bromfenac) produced significant anti-inflammatory activity when applied to the injected paw or to the backs of rats, and the same dose showed topical analgesic activity in the acetylcholine-induced abdominal constriction test in mice[3]. Bromfenac protects against TGF-β1-induced synthesis of fibronectin, α-SMA, and collagen III in human pterygium fibroblasts and primary human conjunctival fibroblasts at least in part by inactivating the AKT and ERK pathways[4]. Bromfenac was well tolerated when given alone or in combination with intravitreal anti-vascular endothelial growth factor agents, topical corticosteroids, or topical mast-cell stabilizers. The most common adverse event reported was ocular irritation[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.81mL

0.56mL

0.28mL

14.04mL

2.81mL

1.40mL

28.08mL

5.62mL

2.81mL
参考文献

[1]Kirkman SK, Zhang MY, et al. Isolation and identification of bromfenac glucoside from rat bile. Drug Metab Dispos. 1998 Jul;26(7):720-3.

[2]Sancilio LF, Nolan JC, et al. The analgesic and antiinflammatory activity and pharmacologic properties of bromfenac. Arzneimittelforschung. 1987 May;37(5):513-9.

[3]Nolan JC, Wagner LE, Gathright CE, Stephens DJ, Sancilio LF. The topical anti-inflammatory and analgesic properties of bromfenac in rodents. Agents Actions. 1988 Aug;25(1-2):77-85

[4]Chen K, Lai K, Zhang X, Qin Z, Fu Q, Luo C, Jin X, Hu J, Liu S, Yao K. Bromfenac Inhibits TGF-β1-Induced Fibrotic Effects in Human Pterygium and Conjunctival Fibroblasts. Invest Ophthalmol Vis Sci. 2019 Mar 1;60(4):1156-1164

[5]Schechter BA. Use of topical bromfenac for treating ocular pain and inflammation beyond cataract surgery: a review of published studies. Clin Ophthalmol. 2019 Aug 1;13:1439-1460