Phenytoin

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Chemical Structure| 57-41-0 同义名 : 5,5-二苯基乙内酰脲 ;5,5-Diphenylhydantoin; NSC 8722; NCI-C55765; Lehydan; Hydantol; Diphenylhydantoin; Diphenylan; Diphenat; Diphedan; Dilabid; Dihycon; Di-Hydan
CAS号 : 57-41-0
货号 : A140185
分子式 : C15H12N2O2
纯度 : 99+%
分子量 : 252.27
MDL号 : MFCD00005264
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(198.2 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • Sodium Channel
描述 Phenytoin (5,5-Diphenylhydantoin) is a potent blocker of Voltage-gated Na+ channels (VGSCs). It is noted for its antiepileptic properties and its ability to reduce breast tumor growth and metastasis in mice[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.96mL

0.79mL

0.40mL

19.82mL

3.96mL

1.98mL

39.64mL

7.93mL

3.96mL
参考文献

[1]Michaela Nelson, et al. The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. Mol Cancer. 2015 Jan 27;14(1):13.

[2]Rogawski, M.A. and W. Loscher, The neurobiology of antiepileptic drugs. Nat Rev Neurosci, 2004. 5(7): p. 553-64.

[3]Porter, R.J., et al., Mechanisms of action of antiseizure drugs. Handb Clin Neurol, 2012. 108: p. 663-81.

[4]Assaggaf MA, Kantarci A, Sume SS, Trackman PC. Prevention of phenytoin-induced gingival overgrowth by lovastatin in mice. Am J Pathol. 2015;185(6):1588-1599.