ASK1-IN-1

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Chemical Structure| 2411382-24-4 同义名 : CAY10756
CAS号 : 2411382-24-4
货号 : A1372186
分子式 : C19H19N9O2
纯度 : 99%+
分子量 : 405.41
MDL号 : N/A
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMF: 4 mg/mL(9.87 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 ASK1-IN-1 is a CNS-penetrant inhibitor of ASK1 (apoptosis signal-regulating kinase 1), exhibiting strong potency with a cellular IC50 of 138 nM and a biochemical IC50 of 21 nM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.47mL

0.49mL

0.25mL

12.33mL

2.47mL

1.23mL

24.67mL

4.93mL

2.47mL
参考文献

[1]Xin Z, et al. Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors. ACS Med Chem Lett. 2020;11(4):485-490. Published 2020 Feb 12.