PfDHODH-IN-1

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Chemical Structure| 183945-55-3 同义名 : -
CAS号 : 183945-55-3
货号 : A1364872
分子式 : C14H11F3N2O2
纯度 : 99%+
分子量 : 296.24
MDL号 : N/A
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(168.78 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 hDHODH-IN-1, an analog of Leflunomide’s active metabolite, inhibits Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) and exhibits antimalarial properties [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.38mL

0.68mL

0.34mL

16.88mL

3.38mL

1.69mL

33.76mL

6.75mL

3.38mL
参考文献

[1]Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide. Int J Mol Sci. 2011;12(5):2982-93.

[2]Hou X, et al. QSAR study on the antimalarial activity of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors. SAR QSAR Environ Res. 2016;27(2):101-24.