Tranexamic acid

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Chemical Structure| 1197-18-8 同义名 : 氨甲环酸 ;cyclocapron; AMCA; Tranexamic Acid, TXA, Trans AMCHA, Cyklokapron; TXA
CAS号 : 1197-18-8
货号 : A127600
分子式 : C8H15NO2
纯度 : 98%
分子量 : 157.21
MDL号 : MFCD00001466
存储条件:

Pure form Keep in dark place, sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

H2O: 50 mg/mL(318.05 mM),配合低频超声助溶

动物实验配方:
生物活性
描述 Tranexamic acid (cyclocapron), a cyclic analog of lysine, is an orally active antifibrinolytic agent. It is used to mitigate the effects of severe trauma and is known for inhibiting urokinase plasminogen activator and enhancing the appearance of dry wrinkles. Tranexamic acid is also researched for its efficacy in promoting hemostasis[1].[2].[3].[4].[5].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01064167 Off Pump Coronary Artery Bypas... 展开 >>s Surgery 收起 << Not Applicable Completed - China ... 展开 >> Cardiovascular Institute and Fuwai Hospital Beijing, China, 100037 收起 <<
NCT01064167 - Completed - -
NCT02279186 Bleeding Phase 4 Unknown September 2015 Egypt ... 展开 >> Ain Shams Maternity Hospital Recruiting Cairo, Egypt, 02 Contact: Nashwa AlSaied, M.D    01005369353 ext 202       Contact: Amr Abdelaziz, M.D    01001783383 ext 202    dr_AmrAziz@hotmail.com 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.36mL

1.27mL

0.64mL

31.80mL

6.36mL

3.18mL

63.61mL

12.72mL

6.36mL

参考文献

[1]Prudovsky I, et al. Tranexamic acid suppresses the release of mitochondrial DNA, protects the endothelial monolayer and enhances oxidative phosphorylation [J]. Journal of cellular physiology, 2019, 234(11): 19121-19129.

[2]Wu G, et al. Tranexamic acid is an active site inhibitor of urokinase plasminogen activator [J]. Blood advances, 2019, 3(5): 729-733.

[3]Draxler D F, et al. Tranexamic acid modulates the cellular immune profile after traumatic brain injury in mice without hyperfibrinolysis [J]. Journal of Thrombosis and Haemostasis, 2019, 17(12): 2174-2187.

[4]Hiramoto K, et al. The amelioration effect of tranexamic acid in wrinkles induced by skin dryness [J]. Biomedicine & Pharmacotherapy, 2016, 80: 16-22.

[5]Sindet-Pedersen S, et al. Hemostatic effect of tranexamic acid mouthwash in anticoagulant-treated patients undergoing oral surgery [J]. New England Journal of Medicine, 1989, 320(13): 840-843.