Carteolol HCl

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Chemical Structure| 51781-21-6 同义名 : OPC-1085 hydrochloride; Carteolol (hydrochloride); Monohydrochloride, Carteolol; Hydrochloride, Carteolol; Abbott-43326; Mikelan; Cartrol; Arteoptic; OPC 1085; NSC 300906; Carteolol hydrochloride
CAS号 : 51781-21-6
货号 : A127362
分子式 : C16H25ClN2O3
纯度 : 98+%
分子量 : 328.83
MDL号 : MFCD00941499
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(152.05 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 25 mg/mL(76.03 mM)
生物活性
靶点

  • β-adrenergic receptor
描述 Carteolol hydrochloride is a non-selective beta blocker used to treat glaucoma.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.04mL

0.61mL

0.30mL

15.21mL

3.04mL

1.52mL

30.41mL

6.08mL

3.04mL
参考文献

[1]Kaji Y, Kiuchi T, Oshika T. Carteolol hydrochloride suppresses the generation of reactive oxygen species and rescues cell death after ultraviolet irradiation of cultured lens epithelial cells. Open Ophthalmol J. 2010 Oct 12;4:60-5.

[2]Kuwahara K, Oizumi N, et al. Carteolol hydrochloride protects human corneal epithelial cells from UVB-induced damage in vitro. Cornea. 2005 Mar;24(2):213-20.