SIRT7 inhibitor 97491

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Chemical Structure| 1807758-81-1 同义名 : -
CAS号 : 1807758-81-1
货号 : A1229053
分子式 : C15H12ClN3O
纯度 : 97%
分子量 : 285.73
MDL号 : MFCD32708524
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 300 mg/mL(1049.95 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • SIRT7

    SIRT7, IC50:325 nM
描述 SIRT7 inhibitor 97491, a powerful SIRT7 inhibitor with an IC50 of 325 nM, diminishes the deacetylase activity of SIRT7 in a dose-dependent fashion. It impedes tumor progression by enhancing p53 stability via acetylation at K373/382 and induces apoptosis via the caspase pathway[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.50mL

0.70mL

0.35mL

17.50mL

3.50mL

1.75mL

35.00mL

7.00mL

3.50mL
参考文献

[1]Ji-Hye Kim, et al. Identification of a Novel SIRT7 Inhibitor as Anticancer Drug Candidate. Biochem Biophys Res Commun. 2019 Jan 8;508(2):451-457.