Urolithin B

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Chemical Structure| 1139-83-9 同义名 : NSC 94726; 3-hydroxy Urolithin
CAS号 : 1139-83-9
货号 : A122397
分子式 : C13H8O3
纯度 : 95%
分子量 : 212.2
MDL号 : MFCD00034338
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(1178.13 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • JNK
描述 Urolithin B (30-100 μM; 24 h) exhibits anti-inflammatory properties in LPS-stimulated BV2 microglia by modulating pro- and anti-inflammatory molecules. It suppresses NF-κB and AP-1 signaling while upregulating AMPK and downregulating the Akt, JNK, and ERK signaling pathways in LPS-stimulated BV2 cells[1]. Urolithin B (15 μM; 24 h) promotes the growth and differentiation of C2C12 muscle ducts through increased protein synthesis and suppression of the ubiquitin-proteasome pathway[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.71mL

0.94mL

0.47mL

23.56mL

4.71mL

2.36mL

47.13mL

9.43mL

4.71mL
参考文献

[1]Lee G, et al. Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia. Phytomedicine. 2019 Mar 1;55:50-57.

[2]Rodriguez J, et al. Urolithin B, a newly identified regulator of skeletal muscle mass. J Cachexia Sarcopenia Muscle. 2017 Aug;8(4):583-597.