SM-7368

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Chemical Structure| 380623-76-7 同义名 : -
CAS号 : 380623-76-7
货号 : A1209325
分子式 : C10H5ClN4O5S
纯度 : 97%
分子量 : 328.69
MDL号 : MFCD00834007
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 85 mg/mL(258.6 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 SM-7368 is a potent NF-kB inhibitor targeting downstream of MAPK p38 activation[1].SM-7368 inhibits TNF-α-induced up-regulation of MMP-9. SM-7368 can be used in chemotherapy studies targeting TNF-α-mediated tumour invasion and metastasis[2].At a concentration of 5 μM, SM-7368 targets downstream of MAPK p38 activation in human colonic crypts (e.g. HT-29 and Caco-2 epithelial cell lines) cells[1].SM-7368 inhibited TNF-α-induced MMP-9 up-regulation in a concentration-dependent manner and showed maximal activity at 10 μM. SM-7368 inhibited a range of TNF-α-induced responses, including MMP-9 mRNA transcript accumulation and protein epitopes, NF-κB activation (but not AP-1 activity), and invasion of the HT1080 cell line[2 ].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.04mL

0.61mL

0.30mL

15.21mL

3.04mL

1.52mL

30.42mL

6.08mL

3.04mL
参考文献

[1]Sabine Kuntz, et al. Carbonyl compounds methylglyoxal and glyoxal affect interleukin-8 secretion in intestinal cells by superoxide anion generation and activation of MAPK p38. Mol Nutr Food Res. 2010 Oct;54(10):1458-67.

[2]Ha Young Lee, et al. A small compound that inhibits tumor necrosis factor-alpha-induced matrix metalloproteinase-9 upregulation. Biochem Biophys Res Commun. 2005 Oct 21;336(2):716-22.