Vanillin

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Chemical Structure| 121-33-5 同义名 : 香草醛 ;p-Vanillin; m-Methoxy-p-hydroxybenzaldehyde; NSC 48383; NSC 403658; NSC 15351; 3-methoxy-4-Hydroxybenzaldehyde; FEMA 3107; p-Hydroxy-m-methoxybenzaldehyde
CAS号 : 121-33-5
货号 : A118216
分子式 : C8H8O3
纯度 : 99%
分子量 : 152.15
MDL号 : MFCD00006942
存储条件：

Pure form Keep in dark place, inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(690.12 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 25 mg/mL(164.31 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
描述 Vanillin, widely used in foods as flavoring, is a major extraction of vanilla bean. It has many biological activities, such as anti-cancer activity, anti-mutagenic activity and so on [1-3] . In vitro studies, vanillin was found to have the ability of inhibiting metastatic gene expression and migration of malignant melanoma cells through the STAT3-HIF-1α signaling pathway [1] . Besides this, vanillin, combined with propylparaben, could inhibit the disappearance of Phenylephrine in LS180 cells [2] . In vivo studies, vanillin was reported to improve histopathological changes of skin in mice, treated with various amounts of vanillin for 7 days. When the mice was given 100 mg/kg vanillin, the thickness and number of cell layers of epidermis in mice would be reduced by 29 ± 14.4 and 27.8 ± 11%. In addition, vanillin could decrease the amount of special immune factors and infiltration of immune cells in the skin of mice [3] .
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02630147 Premature Birth ... 展开 >> Neonatal Hypoxic Conditions 收起 << Not Applicable Unknown September 2017 Canada, Quebec ... 展开 >> Nicu - Chus Recruiting Sherbrooke, Quebec, Canada, J1H5N4 Contact: Valérie Bertelle, MD    (819) 346 1110 ext 14634    valerie.bertelle@usherbrooke.ca    Principal Investigator: Jean-Paul Praud, MD PhD 收起 <<
NCT03626974 Preterm Infant Not Applicable Recruiting November 28, 2020 France ... 展开 >> Assistance Publique Hôpitaux de Marseille Recruiting Marseille, France, 13354 Contact: Muriel BUSUTTIL, PH    491968750 ext +33    muriel.busuttil@ap-hm.fr    Principal Investigator: Catherine GIRE, PH 收起 <<
NCT02851979 Premature Newborns With Gestat... 展开 >>ional Age 28 to 33 Weeks 收起 << Not Applicable Recruiting October 2019 France ... 展开 >> Hopital Femme Mère Enfant Recruiting Bron, France Contact: Hélène GAUTHIER MOULINIER    472 117 647 ext +33    helene.gauthier-moulinier@chu-lyon.fr    CHU de Saint-Etienne Not yet recruiting Saint-Étienne, France Contact: Hugues PATURAL, Pr 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.57mL

1.31mL

0.66mL

32.86mL

6.57mL

3.29mL

65.72mL

13.14mL

6.57mL
参考文献

[1]Park EJ, Lee YM, et al. Vanillin Suppresses Cell Motility by Inhibiting STAT3-Mediated HIF-1α mRNA Expression in Malignant Melanoma Cells. Int J Mol Sci. 2017;18(3).

[2]Zhang Z, Gerk PM. Effects of generally recognized as safe (GRAS) and dietary compounds on phenylephrine metabolism in LS180 human intestinal cells. Biopharm Drug Dispos. 2018;39(9):443-447.

[3]Cheng HM, Chen FY, et al. Oral Administration of Vanillin Improves Imiquimod-Induced Psoriatic Skin Inflammation in Mice. J Agric Food Chem. 2017;65(47):10233-10242.