Pyr3

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Chemical Structure| 1160514-60-2 同义名 : -
CAS号 : 1160514-60-2
货号 : A1176630
分子式 : C16H11Cl3F3N3O3
纯度 : 99%+
分子量 : 456.63
MDL号 : -
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(262.79 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Pyr3 selectively and directly inhibits TRPC3 channels as follows: Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner with an IC50 value of 700 nM. The effect of Pyr3 becomes evident at 0.3 μM, while TRPC3 is almost completely inhibited at 3 μM. Interestingly, Pyr3 inhibited Ca2+ influx in cells expressing both TRPC3 and TRPC6, but not in cells expressing both TRPC1 and TRPC5. Pyr3 inhibited Ang II-induced NFAT translocation in a concentration-dependent manner with an IC50 value of 0.05 μM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.19mL

0.44mL

0.22mL

10.95mL

2.19mL

1.09mL

21.90mL

4.38mL

2.19mL
参考文献

[1]Kiyonaka S, et al. Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5400-5.