Rimeporide

产品说明书

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Chemical Structure| 187870-78-6 同义名 : EMD-87580
CAS号 : 187870-78-6
货号 : A1147312
分子式 : C11H15N3O5S2
纯度 : 99%+
分子量 : 333.38
MDL号 : MFCD30533663
存储条件：

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 18 mg/mL(53.99 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 NHE-1 (sodium-hydrogen exchanger) is a key membrane transporter regulating the intracellular pH, Na+ concentration and catalysing the electroneutral counter transport of Na+ and H+ through the plasma membrane. Rimeporide is a potent and selective NHE-1 inhibitor. It is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent and could therefore be used to treat a broad population of patients with DMD (Duchenne muscular dystrophy). Rimeporide prevented both inflammation and the accumulation of fibrosis in the skeletal muscle and in the heart in mdx mice. Rimeporide prevented hypertrophy, thrombosis and necrosis in the heart of cardiomyopathic hamster. Its cardio-protective effect is most clearly demonstrated by a significant increase in overall survival of treated animals.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.00mL

0.60mL

0.30mL

15.00mL

3.00mL

1.50mL

30.00mL

6.00mL

3.00mL
参考文献

[1]Development of Rimeporide, a sodium-hydrogen exchanger (NHE-1) inhibitor, for patients with Duchenne muscular dystrophy