Cilofexor

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Chemical Structure| 1418274-28-8 同义名 : GS-9674
CAS号 : 1418274-28-8
货号 : A1145754
分子式 : C28H22Cl3N3O5
纯度 : 99%+
分子量 : 586.85
MDL号 : MFCD31731099
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(85.2 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Cilofexor is a nonsteroidal FXR agonist. Cilofexor was well tolerated and led to significant improvements in liver biochemistries and markers of cholestasis in patients with primary sclerosing cholangitis in a 12-week study.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.70mL

0.34mL

0.17mL

8.52mL

1.70mL

0.85mL

17.04mL

3.41mL

1.70mL
参考文献

[1]Trauner M, Gulamhusein A, et al. The Nonsteroidal Farnesoid X Receptor Agonist Cilofexor (GS-9674) Improves Markers of Cholestasis and Liver Injury in Patients With Primary Sclerosing Cholangitis. Hepatology. 2019 Sep;70(3):788-801.